Post-lockdown SARS-CoV-2 nucleic acid screening in nearly ten million residents of Wuhan, China

File attachments: 
AttachmentSize

Post-lockdown SARS-CoV-2 nucleic acid screening in nearly ten million residents of Wuhan, China.pdf1.05 MB

Language
English

9
Average: 9 (1 vote)

Nat Commun
 

. 2020 Nov 20;11(1):5917.
 doi: 10.1038/s41467-020-19802-w.

Shiyi Cao 1, Yong Gan 1, Chao Wang 1, Max Bachmann 2, Shanbo Wei 3, Jie Gong 4, Yuchai Huang 1, Tiantian Wang 1, Liqing Li 5, Kai Lu 6, Heng Jiang 7 8, Yanhong Gong 1, Hongbin Xu 1, Xin Shen 1, Qingfeng Tian 9, Chuanzhu Lv 10, Fujian Song 11, Xiaoxv Yin 12, Zuxun Lu 13

Affiliations expand

Free PMC article

Abstract

Stringent COVID-19 control measures were imposed in Wuhan between January 23 and April 8, 2020. Estimates of the prevalence of infection following the release of restrictions could inform post-lockdown pandemic management. Here, we describe a city-wide SARS-CoV-2 nucleic acid screening programme between May 14 and June 1, 2020 in Wuhan. All city residents aged six years or older were eligible and 9,899,828 (92.9%) participated. No new symptomatic cases and 300 asymptomatic cases (detection rate 0.303/10,000, 95% CI 0.270-0.339/10,000) were identified. There were no positive tests amongst 1,174 close contacts of asymptomatic cases. 107 of 34,424 previously recovered COVID-19 patients tested positive again (re-positive rate 0.31%, 95% CI 0.423-0.574%). The prevalence of SARS-CoV-2 infection in Wuhan was therefore very low five to eight weeks after the end of lockdown.

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1. The occupation distribution of asymptomatic…

 

Fig. 2. The geographic distribution of the…

 

Fig. 3. The prevalence of previously confirmed…

Comment in

Similar articles

See all similar articles

Cited by 30 articles

See all "Cited by" articles

References

    1. WHO. Coronavirus disease 2019 (COVID-19) Situation Report—51. Data as reported by national authorities by 10 AM CET 11 March 2020 (WHO, 2020).
    1. Prevention measures taken at Sanmin residential community in Wuhan—Xinhua | English.news.cn http://www.xinhuanet.com/english/2020-05/11/c_139048342.htm (2020).
    1. Gandhi M, Yokoe DS, Havlir DV. Asymptomatic transmission, the Achilles’ heel of current strategies to control Covid-19. N. Engl. J. Med. 2020;382:2158–2160. doi: 10.1056/NEJMe2009758. - DOI - PMC - PubMed
    1. He D, et al. The relative transmissibility of asymptomatic COVID-19 infections among close contacts. Int. J. Infect. Dis. 2020;94:145–147. doi: 10.1016/j.ijid.2020.04.034. - DOI - PMC - PubMed
    1. Arons MM, et al. Presymptomatic SARS-CoV-2 infections and transmission in a skilled nursing facility. N. Engl. J. Med. 2020;382:2081–2090. doi: 10.1056/NEJMoa2008457. - DOI - PMC - PubMed

Show all 18 references

Publication types

  • Research Support, Non-U.S. Gov't
     

MeSH terms

  • Adolescent
     
  • Adult
     
  • Aged
     
  • Aged, 80 and over
     
  • Antibodies, Viral / immunology
     
  • Asymptomatic Infections / epidemiology
     
  • Betacoronavirus / genetics*
     
  • COVID-19
     
  • Child
     
  • China / epidemiology
     
  • Coronavirus Infections / diagnosis*
     
  • Coronavirus Infections / epidemiology*
     
  • Coronavirus Infections / immunology
     
  • Employment
     
  • Female
     
  • Geography
     
  • Humans
     
  • Male
     
  • Mass Screening*
     
  • Middle Aged
     
  • Nucleic Acids / analysis*
     
  • Pandemics
     
  • Pneumonia, Viral / diagnosis*
     
  • Pneumonia, Viral / epidemiology*
     
  • Pneumonia, Viral / immunology
     
  • Prevalence
     
  • SARS-CoV-2
     
  • Young Adult
     

Substances

  • Antibodies, Viral
     
  • Nucleic Acids
     

Related information

LinkOut - more resources

Link
Post-lockdown SARS-CoV-2 nucleic acid screening in nearly ten million residents…
Source
World Freedom Alliance